CAS No. 133-91-5

Molecular formula: C7H4I2O3

Molecular weight: 389.91

EINECS number 205-124-0

Nature:
- Appearance: 3, 5-diiodosalicylic acid is a white crystalline solid.
Solubility: 3, 5-diiodosalicylic acid is soluble in anhydrous ethanol and methanol, but insoluble in water.

Purpose

1. The field of medicine
(1) Antibacterial and anti-infection
Disinfectants and preservatives:
Iodinated salicylic acid compounds have broad-spectrum antibacterial activity and can be used for skin disinfection or surface treatment of medical devices (similar to the effect of iodoform).

Anti-tuberculosis research
It was historically used as an adjuvant treatment for tuberculosis (combined with iodine to enhance the therapeutic effect), but its application is relatively rare in modern times.

(2) Anti-hyperthyroidism
Thyroid inhibitor
The release of iodine may interfere with the synthesis of thyroid hormones and was once used for the temporary control of hyperthyroidism (now replaced by safer drugs).

(3) Drug intermediates
Used for synthesizing more complex drug molecules, such as:

X-ray contrast agent (iodinated aromatic compounds are common structures of contrast agents).

Modified precursors of non-steroidal anti-inflammatory drugs (NSAIDs).

2. Agricultural field
Fungicide
It has a certain inhibitory effect on plant pathogenic fungi (such as powdery mildew and rust) and can be used for crop protection (further formulation optimization is needed).

Growth regulator
Iodophenolic acid substances may affect the metabolism of plant hormones and regulate growth.

3. Chemical Synthesis and Materials Science
Organic synthesis intermediates

By taking advantage of the high reactivity of iodine atoms, they participate in coupling reactions (such as Suzuki coupling and Ullmann reactions) to construct complex aromatic systems.

Used for synthesizing liquid crystal materials or functional polymers.

Analytical reagents:
As a chromogenic agent or complexing agent, it is used to detect metal ions (such as iron and copper by colorimetric method).

4. Other uses
Laboratory research

Study the metabolic pathways of iodinated aromatic compounds (such as deiodinase activity).

Used as a standard substance in analytical chemistry (HPLC or mass spectrometry detection).